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? 負(fù)責(zé)3個(gè)跨機(jī)構(gòu)科研合作項(xiàng)目的管理工作，合作方為香港中文大學(xué)。共管理資金500萬港幣，并通過起草和執(zhí)行資金管理策略，包括與銷售人員制定銷售協(xié)議，為兩機(jī)構(gòu)共節(jié)省20萬元港幣。管理過程中，按時(shí)以PPT和郵件方式向?qū)嶒?yàn)室負(fù)責(zé)人和合作伙伴匯報(bào)進(jìn)程，并和合作方管理人員保持緊密聯(lián)系以確保項(xiàng)目的順利進(jìn)行以及項(xiàng)目目標(biāo)的完成。 ? 管理3組由2到4名本科和博士生組成的研究團(tuán)隊(duì)，負(fù)責(zé)溝通解決項(xiàng)目進(jìn)行中出現(xiàn)的人事糾紛和技術(shù)性問題，并對(duì)科研問題給予專業(yè)指導(dǎo)。修改4篇由作者擬好的英文學(xué)術(shù)文章并輔助文章在國際期刊的順利發(fā)表。 ? 管理科研數(shù)據(jù)。 Managed 3 cross-organizational projects with total government grants worth of HK$5 million ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals ? 建立兩個(gè)可以用于商業(yè)化的 CRISPR-Cas9 基因敲除穩(wěn)定細(xì)胞系。 ? 建立了3個(gè)新型激酶在人體內(nèi)的作用對(duì)象的數(shù)據(jù)庫，并完善了利用概率來篩選和分析蛋白分子互動(dòng)對(duì)象的數(shù)學(xué)方法。 ? 設(shè)計(jì)并完成關(guān)于幾類新型激酶在卵巢癌和肝癌的發(fā)展和轉(zhuǎn)移中所起作用的研究，其中，明確確定了SBK1激酶在卵巢癌發(fā)展中的作用。研究中運(yùn)用到生物細(xì)胞學(xué)、生物化學(xué)、蛋白學(xué)、統(tǒng)計(jì)學(xué)和動(dòng)物模型等實(shí)驗(yàn)方法。 ? 與學(xué)院內(nèi)蛋白小分子、干細(xì)胞等實(shí)驗(yàn)組以及香港中文大學(xué)某實(shí)驗(yàn)室取得了合作，并帶領(lǐng)、輔導(dǎo)2支國外本科交流實(shí)習(xí)生隊(duì)伍參與與此課題相關(guān)的實(shí)驗(yàn)。 ? 起草并提交實(shí)驗(yàn)室科研經(jīng)費(fèi)申請(qǐng)。 Led a large-scale research project to investigate the activities of previously unknown kinases in ovarian and hepatic cancer ? Generated 2 CRISPR-Cas9 stable gene knockout cell lines available for commercial use ? Developed a probability-based algorithm to screen and analyze protein inter candidates ? Established kinase targets databases for 3 novel kinases ? Verified the mechanism of novel gene SBK1 in ovarian cancer metastasis ? Mentored 2 groups of international undergraduate interns ? Collaborated with teams in FHS and the Chinese University of Hong Kong ? Prepared and submitted proposals for grant applications in line with group strategies ? Executed a series of experiments on protein characterization, protein-protein inter and functional assays in vitro and in vivo

? 建立了與包括加拿大國家中子中心、 勞厄-朗之萬研究所（法國）、Helmholtz-Zentrum Berlin（HZB德國）、巴斯大學(xué)、拉塞福-阿普頓實(shí)驗(yàn)室、格拉斯哥大學(xué)和羅斯林研究所（英國）在內(nèi)的7所國際知名科研中心的學(xué)術(shù)合作，并多次獲得中子機(jī)構(gòu)給予的科研經(jīng)費(fèi)。期間與10多個(gè)由多學(xué)科人員組成的當(dāng)?shù)貓F(tuán)隊(duì)一起工作，與主要人員建立了長期合作關(guān)系。 ? 通過物理學(xué)和數(shù)據(jù)分析來研究艾滋海默癥病理。物理學(xué)采用包括光學(xué)、分子運(yùn)動(dòng)學(xué)和中子衍射等一系列物理學(xué)原理來學(xué)習(xí)該病病原淀粉樣蛋白的物理結(jié)構(gòu)及結(jié)構(gòu)變化，以及該蛋白在不同結(jié)構(gòu)下對(duì)細(xì)胞磷脂層的作用；數(shù)學(xué)主要應(yīng)用傅立葉變化將由中子衍射發(fā)出的信號(hào)轉(zhuǎn)變?yōu)榱字肿幽Ｐ停M(jìn)而分析磷脂在淀粉樣蛋白作用下的變化。博士畢業(yè)論文：淀粉樣蛋白和磷脂細(xì)胞的相互作用關(guān)系。 ? 創(chuàng)立了體外控制淀粉樣蛋白聚集的方法。 ? 改進(jìn)并完善了利用Langmuir膜和布魯斯特角顯微鏡來觀測(cè)磷脂單分子層在水與空氣交接面的狀態(tài)的方法。 Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics Thesis title: The inter between Amyloid beta peptide and lipid membranes ? Established collaborations with 7 world-renowned institutes including Canadian Neutron Beam Centre, The Institute Laue-Langevin, Helmholtz-Zentrum Berlin, University of Bath, Rutherford on Laboratory, University of Glasgow and the Roslin Institute ? Worked in 10+ multidisciplinary teams in Europe and Canada to identify the structural characteristics of amyloid protein and the biophysics of protein-lipid inters received neutron beam time al and traveling grants from neutron scattering facilities ? Performed mathematical analysis based on Fourier transform to generate membrane profile from neutron diffr data sets and predict protein penetration position ? Created a novel methodology to protein folding rate in non-physiological environments ? Improved Langmuir trough and Brewster Angle Microscopy techniques to monitor lipid mono dynamics at air-water interface

應(yīng)用物理和數(shù)學(xué)方法學(xué)習(xí)阿茲海默癥病理/ Studied the mechanism of Alzheimer’s disease using biophysics and advanced analytics

獸醫(yī)病理學(xué)/ Veterinary Pathology 獸醫(yī)臨床/ Veterinary Surgery 生物/ Biology 有機(jī)化學(xué)/ Organic Chemistry

負(fù)責(zé)3個(gè)跨機(jī)構(gòu)科研合作項(xiàng)目的管理工作，合作方為香港中文大學(xué)，共管理資金500萬港幣/ Managed 3 cross-organizational research projects with total government grants worth of HK$5 million

? 通過起草和執(zhí)行資金管理策略，包括與銷售人員制定銷售協(xié)議，為兩機(jī)構(gòu)共節(jié)省20萬元港幣。管理過程中，按時(shí)以PPT和郵件方式向?qū)嶒?yàn)室負(fù)責(zé)人和合作伙伴匯報(bào)進(jìn)程，并和合作方管理人員保持緊密聯(lián)系以確保項(xiàng)目的順利進(jìn)行以及項(xiàng)目目標(biāo)的完成。 ? 管理3組由2到4名本科和博士生組成的研究團(tuán)隊(duì)，負(fù)責(zé)溝通解決項(xiàng)目進(jìn)行中出現(xiàn)的人事糾紛和技術(shù)性問題，并對(duì)科研問題給予專業(yè)指導(dǎo)。修改4篇由作者擬好的英文學(xué)術(shù)文章并輔助文章在國際期刊的順利發(fā)表。 ? 管理科研數(shù)據(jù)。 ? Developed and executed strategies for all 3 projects that yielded a total 4% cost reduction ? Supervised 3 teams of 2–4 junior researchers responsible for guiding teams towards milestone deliverables and resolving conflict situations ? Monitored progress and ensured projects meet deadlines in a timely and accurate fashion ? Liaised with external management to exchange information, promote efficiency and ensure project goals are achieved ? Negotiated with venders and achieved business agreements ? Provided regular updates on progress to lab director and collaborators through data presentations and written reports ? Provided expertise on study design and research methodology ? Troubleshooted experimental and technical problems ? Managed and securely stored data ? Reviewed 4 articles intended for publication in internally recognized journals